Urigen


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Composition and Strength: Potassium Citrate

Form: 1100 mg & citric acid 334 mg/ 5ml

Packaging: Oral Solution

Description : 100 ml & 200 ml  PET bottle       Urinary alkalinizing agent

Description
 
URIGEN is a stable and pleasant-tasting oral systemic alkalizer containing potassium citrate and citric acid in a sugar-free, non-alcoholic base.
It is useful in those conditions where long term maintenance of alkaline urine is desirable, such as in patients with uric acid and cystine calculi of the urinary tract, especially when the administration of sodium salts is undesirable or contraindicated.
 
URIGEN contains in each teaspoonful (5 ml):-
 
Potassium Citrate Monohydrate         1100 mg
Citric Acid Monohydrate                   334 mg
 
Each ml contains 2 mEq potassium ions and is equivalent to 2 mEq bicarbonate (HCO3).
 
Mode of Action

Potassium Citrate is a urinary alkalinizing agent. When administered orally, the absorbed potassium citrate is metabolized to potassium bicarbonate, thus increasing the urinary pH by increasing the excretion of free bicarbonate ions, without producing systemic alkalosis when administered in recommended doses.

The changes induced by Potassium Citrate produce urinary pH that is less favorable to the crystallization of stone-forming salts (calcium oxalate, calcium phosphate and uric acid). Increased citrate in the urine decreases calcium ion activity by complexing with calcium and thus decreases the saturation of stone-forming calcium salts like oxalate.

A rise in urinary pH increases the solubility of cystine in the urine and the ionization of uric acid to more soluble urate ion. By maintaining alkaline urine, the actual dissolution of uric acid stones may be accomplished.

Indication
 
·         URIGEN is an effective alkalinizing agent useful in those conditions where short and long-term maintenance of alkaline urine is desirable such as in patients with uric acid and cystine calculi of the urinary tract.
 
By raising urine pH, the risk of uric acid stones in the kidneys developing is reduced. This risk is high among gout sufferers. About 20% of gout patients with acidic urine will develop uric acid kidney stones if remained untreated.

Potassium citrate has even been shown to dissolve uric acid kidney stones or halt their further development.


·         It is a valuable adjuvant when administered with uricosuric agents in gout therapy, since urates tend to crystallize out of in acid urine. It also helps to keep uric acid levels lower thus preventing a repeat gout attack.
 
·         It is also effective in correcting the acidosis of certain renal tubular disorders where the administration of potassium citrate may be preferable.
 
·         For symptomatic relief from burning and painful urination associated with urinary tract infections like Urethritis, Prostatitis and Cystitis
 
·         Also used to prevent or treat hypocitraturia in patients with calcium renal calculi
 
 
 
Dosage and administration:
 
It should be taken diluted in water according to directions, followed by additional water, if desired. Palatability is enhanced if chilled, and not freeze, before taking.
Drink the mixture slowly, over 5 to 10 minutes in all. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.
 
Usual Adult Dose: 3 to 6 teaspoonfuls (15 to 30 ml), diluted with 1 glass of water, after meals and at bedtime, or as directed by a physician.
 
Usual Pediatric Dose: 1 to 3 teaspoonfuls (5 to 15 ml), diluted with 1/2 glass of water, after meals and at bedtime, or as directed by a physician.
 
Usual Dosage range: 2 to 3 teaspoonfuls (10 to 15 ml), diluted with a glassful of water taken four times a day. Potaasium citrate and Citric Acid Oral Solution USP diluted with a glassful of water taken four times a daywill usually maintain a urinary pH of 7.0-7.6 throughout most of the 24 hrs without producing any unpleasant side effects.    

Note: Dosage should be adjusted as determined by urinary pH measurements



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